How Much Nicotine Is in a Vape? How Many Puffs of a 20MG Vape Is Equal to a Cigarette? Say no to vaping. 10 15 vape puffs are roughly equivalent to one cigarette. We want to encourage and support families to have open and engaging conversations with young people to Youth often mistakenly believe vaping concentrates are harmless, but the concentration of nicotine and chemicals is shocking. Did you know? One disposable vape (up to 5,000 puffs) can equal the nicotine content