Lithium OrotateCompare to Lithium Orotate by Purely Integrative The Lithium Orotate formula supports a positive mental outlook, supports detoxification enzymes in the brain, and boosts neurotransmitter activity. Though its exact mechanism of action in the brain is still unidentified, lithium has been shown in the research to boost neurotransmitter activity, including that of dopamine and serotonin, and to reduce the activity of the excitatory brain chemical