I Love Someone With Down Syndrome-Awareness Day or Month TeeMachine wash cold with like colors, dry low heat Show your love for that special person in your life with this t shirt. World Down Syndrome Day (WDSD) is observed on March 21. Three #21 chromosomes or Trisomy 21 results in down syndrome. We observe World Down Syndrome day on 3 21 each year or March 21st. A blue and yellow floral awareness ribbon design. Wear in October for Down Syndrome Awareness Month. Down Syndrome isn't scary, it's exciting! akes a